The atopic dermatitis trial landscape
Atopic dermatitis is one of the most competitive therapeutic areas in immunology-driven drug development. Dupilumab's commercial success, blockbuster revenues exceeding $10B annually, has attracted every major immunology company to the space. The result is a dense, complex trial landscape with overlapping mechanisms, pediatric extensions, and aggressive head-to-head programs.
For dermatology pharma and biotech teams, keeping up with new trial registrations across IL-4/IL-13, JAK inhibitors, OX40, TSLP, IL-31, and emerging mechanisms requires systematic monitoring. DataLookout automates this work.
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Sign Up FreeA primary completion date pushed out, enrollment cut, or a primary endpoint changed in the last 90 days. Active trials only.
| Trial | Warning signs | Status |
|---|---|---|
| A Double-Blind, Randomized, Vehicle-Controlled Phase 2 Study to Assess the… NCT07355075 | Primary completion moved at least 6 months later Primary endpoint(s) modified | Recruiting |
21 more on the Trials at Risk page. See which trials →
Phase 2 and Phase 3 trials with a primary completion date in the next 180 days, as ClinicalTrials.gov estimates it today. Active trials only.
| Trial | Scheduled | Phase |
|---|---|---|
| A Study of JNJ-95597528 in Participants With Moderate to Severe Atopic… NCT07230860 | Nov 19, 2026 · Estimated | Phase 2 |
29 more on the Completions page. See the calendar →
Key mechanisms generating new atopic dermatitis trials
IL-4/IL-13 dual inhibition and selective targeting
Following dupilumab (IL-4Rα), the second wave targets related cytokines with higher selectivity or improved dosing profiles. Programs include:
- Subcutaneous anti-IL-13 antibodies with monthly or less frequent dosing
- Next-generation IL-4Rα antibodies with extended half-life and self-injection devices
- Tralokinumab (IL-13 selective) follow-on combination studies
- Bispecifics combining IL-4/IL-13 with TSLP or OX40L blockade
JAK inhibitors: oral and topical
Three JAK inhibitors are approved for moderate-to-severe AD (baricitinib, upadacitinib, abrocitinib). New trial activity focuses on:
- JAK1-selective inhibitors with improved tolerability profiles
- Topical JAK inhibitors for mild-to-moderate disease (ruxolitinib cream approved; new entrants in development)
- Combination of oral JAK inhibitors with dupilumab for refractory patients
- Long-term safety extensions and real-world evidence studies
OX40 and OX40L: memory T cell targeting
OX40 pathway blockade addresses AD at the memory T cell level, potentially offering longer disease modification. Rocatinlimab (anti-OX40) is in late-stage development; amlitelimab (anti-OX40L) has shown Phase 3 data. New trials are exploring:
- Combination with IL-4/IL-13 inhibitors for refractory patients
- OX40 in pediatric populations and prevention studies
- Long-term maintenance and treatment-free remission protocols
TSLP and IL-33 upstream inhibition
Tezepelumab (anti-TSLP) showed modest activity in AD; next-generation TSLP and IL-33 programs are testing higher dose levels, pediatric populations, and combination strategies. Itepekimab (anti-IL-33) has an active AD program.
Novel topical and non-systemic approaches
For mild-to-moderate AD, the development pipeline has expanded beyond TCS/TCI to include:
- PDE4 inhibitors (crisaborole follow-ons with improved potency and tolerability)
- Aryl hydrocarbon receptor (AhR) modulators: tapinarof approved; next-generation compounds in trials
- IL-31 antagonists targeting itch specifically (nemolizumab Phase 3)
- Microbiome-targeted approaches (Staphylococcus aureus decolonization strategies)
Who monitors atopic dermatitis clinical trials?
- Dermatology business development and competitive intelligence teams at companies with AD pipelines tracking competitor enrollment and mechanism status
- Clinical development leaders designing new AD trials who need a comprehensive view of what's running in the space
- Medical affairs and MSL teams at companies with marketed AD therapies needing current competitor trial data
- Healthcare analysts covering dermatology-focused biotech and pharmaceutical companies
- Pediatric dermatologists needing to know what trials are enrolling for children with moderate-to-severe AD
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Get Started FreeRelated immunology and dermatology trial monitors
- Rheumatoid arthritis clinical trials: overlapping JAK inhibitor programs and shared biologics platforms
- Lupus clinical trials: shared immunology mechanisms, type I interferon biology
- Crohn's disease clinical trials: shared IL-23, JAK, and TL1A programs across immunology
346 active trials, 180 recruiting.
Industry sponsors run 190 of these trials. The rest are run by universities, hospitals, government bodies and other non-commercial sponsors. The table below lists the 5 largest of 106.
| Top industry sponsor | Active trials |
|---|---|
| Sanofi | 16 |
| Pfizer | 14 |
| AbbVie | 9 |
| Keymed Biosciences Co.Ltd | 5 |
| Almirall, S.A. | 4 |
| Trial | Status | Latest tracked change | Seen |
|---|---|---|---|
| Study of ADSTEM Injection for Patients With Moderate to Severe Subacute and… NCT07377838 | Recruiting | Primary completion pushed from Jun 2029 to Sep 2029 | 2026-11-14 |
| A Study of the Medicine Called Abrocitinib in Children 6 to Less Than 12 Years… NCT06807268 | Active, Not Recruiting | Enrollment closed, study ongoing | 2026-11-13 |
| A Study to Investigate Safety and Efficacy of Tapinarof Cream, 1% in… NCT07265479 | Active, Not Recruiting | Trial status changed | 2026-11-11 |
| Michigan Food and Atopic Dermatitis (M-FAD) Program - Molecular Analytics… NCT06300697 | Recruiting | Study completion pushed from Mar 2027 to Mar 2028 | 2026-11-11 |
| Thera-Clean® Microbubbles System in Patients With Skin Diseases NCT07050810 | Enrolling by Invitation | Study completion pushed from Feb 2027 to Aug 2027 | 2026-11-10 |
Each trial page shows every change DataLookout has recorded for that trial.
DataLookout checks ClinicalTrials.gov every day and records what changed on each trial: status, enrollment, phase, primary endpoint, completion dates, sites, sponsor, and the stated reason a trial stopped. Add a sponsor or a disease to your watchlist, or save any search, and the changes arrive in a daily or weekly email digest.
Free, $0 forever: 1 sponsor + 1 disease watchlist, 1 saved search in your email digest, track up to 5 individual trials, daily change detection, Trials at Risk (top 2 trials). No credit card.
Pro, $49/month or $490/year: 10 sponsor + 10 disease watchlists, 10 saved searches in your email digest, track up to 25 individual trials, full Trials at Risk list, Completions calendar, landscape reports, CSV export.