Lung Cancer clinical trial landscape

Lung cancer is the most trial-active solid tumor on ClinicalTrials.gov. DataLookout monitors it daily across both major histologies and every actionable molecular driver, then delivers a morning digest of new studies and protocol changes.

Track Lung Cancer trials, free
3893
Active trials
2129
Actively recruiting
378
Phase 3 active
1260
Distinct sponsors

Data as of 2026-11-14.

The lung cancer trial landscape in 2026

Lung cancer splits into two clinically distinct histologies. Non-small cell lung cancer (NSCLC) accounts for the large majority of trials and is increasingly segmented by molecular driver, EGFR, KRAS G12C, HER2, ALK, ROS1, BRAF, and RET, each with its own targeted-therapy program. Small cell lung cancer (SCLC) is a separate, faster-growing histology with a distinct trial set. A useful lung-cancer competitive picture has to track both the histology split and the molecular-subtype races at once.

Active lung cancer trials by subtype

Molecular-driver subtypes are subsets of NSCLC and overlap each other, so the rows below do not sum to the total above, each links to a dedicated biomarker landscape. KRAS G12C spans lung, colorectal, and pancreatic cancer; its page covers all indications.

By histology

SubtypeActiveRecruitingPhase 3
Non-Small Cell Lung Cancer (NSCLC)25721359304
Small Cell Lung Cancer (SCLC)50428056

By molecular driver (within NSCLC)

SubtypeActiveRecruitingPhase 3
EGFR-mutant39219359
KRAS G12C713316
HER2-mutant87528
ALK-positive73288
ROS1 fusion38196
BRAF V600E1040
RET fusion822

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Most active industry sponsors

Largest industry-sponsored lung cancer trial portfolios by active study count:

What we monitor

Our pipeline pulls from ClinicalTrials.gov every day. For a lung cancer watchlist or saved search, your digest covers:

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FAQ

Frequently asked questions

How many lung cancer clinical trials are actively recruiting?
2129 lung cancer trials are actively recruiting on ClinicalTrials.gov, out of 3893 active studies overall (recruiting, not yet recruiting, active but not recruiting, or enrolling by invitation), including 378 in Phase 3. Counts on this page regenerate from ClinicalTrials.gov on every update.
What is the difference between NSCLC and SCLC trials?
Non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) are distinct histologies with separate standards of care and trial sets. NSCLC trials are further segmented by molecular driver (EGFR, KRAS G12C, ALK, ROS1, HER2, BRAF, RET); SCLC trials are tracked on their own dedicated page.
Can I track a single lung cancer subtype?
Yes. Each subtype in the table above has its own landscape page, and in the dashboard you can create a watchlist scoped to one driver (for example EGFR-mutant or KRAS G12C) and receive a separate daily digest for it.
Track these trials with DataLookout

DataLookout checks ClinicalTrials.gov every day and records what changed on each trial: status, enrollment, phase, primary endpoint, completion dates, sites, sponsor, and the stated reason a trial stopped. Add a sponsor or a disease to your watchlist, or save any search, and the changes arrive in a daily or weekly email digest.

Free, $0 forever: 1 sponsor + 1 disease watchlist, 1 saved search in your email digest, track up to 5 individual trials, daily change detection, Trials at Risk (top 2 trials). No credit card.

Pro, $49/month or $490/year: 10 sponsor + 10 disease watchlists, 10 saved searches in your email digest, track up to 25 individual trials, full Trials at Risk list, Completions calendar, landscape reports, CSV export.

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Data as of 2026-11-14, from ClinicalTrials.gov. View the full pipeline on the dashboard.